Macula Densa Control of Renin Release and Glomerular Hemodynamics.
نویسندگان
چکیده
منابع مشابه
Macula densa sensing and signaling mechanisms of renin release.
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis...
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It is well established that two microanatomical areas of the kidney (macula densa and juxtaglomerular cells) are in some way associated with the secretion of renin. However, their precise role in the regulation of this hormone remains unresolved. Controversy still exists as to whether the rate of renin secretion is controlled solely by a pressure and stretch sensitive receptor in the juxtaglome...
متن کاملRole of the macula densa in renin release.
To examine the role of the macula densa in renin release, afferent arterioles alone or afferent arterioles with the macula densa attached were microdissected from rabbit kidney and incubated in Medium 199 for two consecutive 30-minute periods. Renin concentration in the medium was measured using partially purified rabbit angiotensinogen. Renin release rate over 1 hour from a single arteriole (o...
متن کاملRole of macula densa in diuretics-induced renin release.
Diuretic therapy may enhance renin release by various mechanisms, principally contraction of extracellular fluid volume and its effects, including a fall in arterial pressure. Awake hydropenic or volume-expanded rats received diuretics (amiloride and hydrochlorothiazide) that are known inhibitors of NaCl transport beyond the macula densa; also the well-known Na(+)-K(+)-2 Cl- transport system in...
متن کاملEvidence for the role of nitric oxide in macula densa control of glomerular hemodynamics.
There is evidence that nitric oxide, an endothelium-derived relaxing factor, may be produced by the macula densa, as well as by blood vessels, within the kidney. To examine the role of nitric oxide in macula densa control of glomerular hemodynamics directly, we performed in vitro microperfusions of both rabbit afferent arterioles (with the glomerulus intact) and adherent tubular segments consis...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1992
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.166.27